With every unblocked attack the player lands on an enemy, that enemy comes closer to becoming dizzy.

If the player hits a guarding enemy enough times in a row, they will immediately break through Gene's combo with a counter-attack, often launching into a combo of their own. When an enemy's guard is broken, they are thrown into their broken guard animation, allowing the player several hits before the enemy is able to guard again. Enemies can start to block during the player's combo, requiring the player to either wait for the enemy to stop blocking or use a move that breaks their guard. Unlike Gene, the enemies are able to block attacks. Dodges can also be used to cancel out of attack animations, which is useful for moves with long recovery time.

The right joystick on the dual shock controller is dedicated only to evading, with up doing a quick duck, left and right sidestepping, and back doing a back-flip. Rather than be able to block, the player is only able to dodge or evade enemy attacks. X, Triangle, Down + X, Down + Triangle and Down + Square can also be assigned their own singular attacks, though those attacks cannot be strung together like a combo. While seemingly simplistic, the player must consider the speed, fluidity, power, number of hits, and other special benefits of attacks such as the ability to launch an opponent or fill the Tension Gauge. Players can assign any combination of the game's 100 fighting moves into a four attack combo (though it eventually can become a string of five or six attacks with upgrades) mashing the square button fires off these attacks in the order assigned. God Hand is a brawler that draws much of its inspiration from games of the same genre from the 16 bit era, while still putting its own unique twist on the genre. God Hand was released as a downloadable game for the PlayStation Network US on October 4, 2011. It is also known for its humorous and sometimes nonsensical story and eclectic, off-beat soundtrack. God Hand takes place in punk setting similar to other such properties as Mad Max and Fist of the North Star. It is a 3D brawler, taking inspiration from games like Streets of Rage and Final Fight from the 16-bit era, that was released in late 2006. God Hand was the last game made by the now defunct Clover Studio, and directed by Resident Evil creator Shinji Mikami.

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